The antioxidative phytochemicals in medicinal plants have received increasing attention for their potential role in prevention of human diseases The antioxidant potential of the ethanolic & aqueous extract of leaves of Pongamia pinnata was assessed by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) & H2O2 reducing power and total phenolic content was measured by Folin-Ciocalteau (FC) by Singleton and Rossi using Gallic acid as the calibration standard. Moreover Pongamia pinnata leaf ethanolic extract showed strong reducing power and significant antioxidant activity. In the H2O2 radical scavenging assay, the IC50 value of the Pongamia pinnata leaf ethanolic & aqueous extract was found to be 41.25 & 43.85 μg/mL respectively. The total phenolic content was measured by Folin-Ciocalteau was found 55.7 & 31.3 mg/g of the ethanolic & aqueous extract respectively, while IC50 value of the Pongamia pinnata ethanolic & aqueous extract with respect to DPPH is found to be 432.08 & 448.18. More in vitro and in vivo studies along with detailed photochemical investigation are needed in the hope to can use these species (crude extract, fractions, sub-fractions or pure compounds) in the prevention and therapies of diseases in which oxidants or free radicals are involved
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